Liao H, Liu P, Hu Y, Wang D, Lin H
[Antidepressant-like effects of piperine and its neuroprotective mechanism] [English Abstract, Journal Article]
Zhongguo Zhong Yao Za Zhi 2009 Jun; 34(12):1562-5.
OBJECTIVE: To observe the antidepressant effect of piperine and its neuroprotective mechanism.
METHOD: The behavioral studies were performed in forced swimming test (FST) and tail suspension test (TST). To further explore the mechanisms underlying their antidepressant-like activities, CORT-induced neuroblastoma SH-SY5Y cells and isolated and cultured neural progenitor cells. By using MTT assay, the effect of piperine on neural cells proliferation was observed.
RESULT: The research results indicated that after a week of administration, piperine (10, 20 mg x kg(-1)) could significantly reduce the duration of immobility in both FST and TST. Piperine has the protective effect on neuroblastoma cells and increased proliferation of hippocampus neural progenitor cells.
CONCLUSION: In the present study, we demonstrated that the antidepressant-like effects of piperine and its mechanisms might be involved by up-regulation of the progenitor cell proliferation of hippocampus and cytoprotective activity.
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